Therefore, this study investigated the antidiabetic and antioxidant activities and also the toxicity of seed extract from l. However, due to the potential toxicity of the plant extract it must be prescribed with caution. In the present study, the whole plant was selected in case of herbs, leaves and stem in case of shrubs and leaves in case of trees on the basis of availability of phytoconstituents. Hence, the antidiabetic action of the plant latex may be due to prevention of oxidative stress, inhibition of carbohydrate metabolizing enzymes, and reduction of absorptions of cholesterol from the gut and also could be due to the stimulation insulin release from residual. Antidiabetic activity of different extracts of myrtus. Pdf antidiabetic activity of ethanolic extract of sesbania grandiflora. Abutilon antidiabetic activity pdf buecher wuermer. Phytochemical and in vitro antidiabetic activity of psidium. In the present study, we have evaluated terminalia chebula, terminalia belerica, emblica officinalis, their combination triphala for their antidiabetic activity and their relation with their antioxidant activity.
By acute toxic class method swiss albino mice of female sex weighing 2025gms were used for the study. Antidiabetic activity and phytochemical screening of extracts. In our study, the butanol fractions of selected plant species generally have been found more active than other fractions, indicating that compounds having antidiabetic activity are polar in nature which established the significant. Therefore, further investigation needs to be performed. Plant material was subjected to the extraction preparation by soxhlet apparatus by using various solvents such as aqueous, ethanol, chloroform. Natural antimicrobials and antidiabetic plant extracts. Plants have been the primary source of drugs and many of the currently available drugs have been directly or indirectly derived from plants. Further study to substantiate the use of the plant as antidiabetic is recommended. The aim of this research was to investigate antidiabetic activity of costus igneus also known as insulin plant leaves extracts in alloxan induced diabetic albino rats. Pdf herbal medicines are commonly measured to be fewer toxic and also free from side effects, than synthetic ones. This study aimed to evaluate the antidiabetic and antihyperlipidemic effects of the leaf latex extract of a. Antioxidant and antidiabetic activities of the methanolic. The findings from this study therefore support the folkloric usage of b. Frontiers evaluation of antioxidant, antidiabetic and.
In vitro and in vivo antidiabetic effect of extracts of. Asian journal of plant science and research, 2011, 1 2. Aegle marmelos, alloxan, antidiabetic, hyperglycemia. Antidiabetic herbal drugs and polyherbal formulation used. Present study was taken up to evaluate the antidiabetic activity of alpinia galangal and to establish its therapeutic potential in the treatment of diabetes and its complication 3. Antidiabetic herbal drugs and polyherbal formulation used for. Determination of in vitro antidiabetic effects of zingiber.
Aqueous extracts of zingiber officinale rhizomes were studied to evaluate their antidiabetic effects on protein glycation and on the diffusion of glucose in vitro in the present study. This research aims to investigate the antidiabetic activity of nerium indicum family. Aqueous extracts of the plants were prepared by maceration. Antidiabetic and antihyperlipidemic activities of the leaf latex. Antidiabetic potential of biophytum sensitivum whole plant. Antidiabetic activity of aqueous and methanol extract and fractions of gongronema latifolium leaves in alloxan diabetic rats p. The ethanol and aqueous extracts showed a significant.
There was a dosedependent increase in percentage inhibitory activity against alphaamylase enzyme. Antidiabetic activity of herbal drugs dwiti modak ayurvedic pharmacy, lovely school of pharmaceutical sciences, lovely professional university, phagwara, punjab, india dwiti. Pdf antidiabetic activity of insulin plant costus igneus. Multiple plant extracts derived products are available in asian herbal markets as antidiabetic agents like. Myrica gale ethanol extract exhibited the highest inhibition of. In vitro antidiabetic activity of caesalpina digyna r. Antidiabetic and antioxidant activities of roylea cinerea. The extracts produced a significant antidiabetic effect on first, third, fifth and seventh days at 300 mgkg body weight.
Introduction antidiabetic drugs treat diabetes mellitus by lowering glucose levels in the blood. The activity of these plant extracts can be attributed to phytoconstituents present in them, such as flavonoids, alkaloids, terpenoids, anthocyanins, glycosides, phenolic compounds. Plant material was subjected to the extraction preparation by soxhlet apparatus by using various solvents such as aqueous, ethanol, chloroform, petroleum ether and hexane. The methanolic extract of leaf of catharanthus roseus l at a dose of 200 mgkg and 400 mgkg body weight was induced through intraperitonial in mice. In vitro studies on alpha amylase and alpha glucosidase. Physalis minima is widely used in indian medicine by the tribal communities to treat.
Antidiabetic activity of methanolic extract of hibiscus cannabinnus in streptozotocin induced diabetic rats. Potential antidiabetic activity of medicinal plants a. The polyphenol content in green tea might contribute to anti diabetic activities. Antidiabetic activity testing was carried out bygiving llse at an oral dose of 250 mgkg body weight to streptozotocininduced diabetic rats daily for 6 wk. May 02, 2017 treatment with the antidiabetic drug, glibenclamide 10 mgkg body weight lowered blood glucose level by 51. Jul 07, 2019 isolation, characterization and evaluation of anticonvulsant activity of rubus antidiabetic activity of the plant abutilon indicum in streptozotocin induced. Antioxidant and antidiabetic activities of methanolic. Diabetes mellitus is one of the most common noncommunicable diseases globally. Here the diameter and the computed area of zone of inhibition have been used as a gauge of the plant s antimicrobial activity. Among all the extracts of dalbergia sissoo, ethanol extract of leaves exhibited highly significant antidiabetic activity are comparable with the standard. Antidiabetic activity of syzygium cumini and its isolated compound against streptozotocininduced diabetic rats. Introduction in folk medicinal practice many plants are used to treat diabetes mellitus in south india. The best concentration and time required to incubate glucose with hemoglobin was estimated. However, antidiabetic activity was seen when the extract.
More number of plant and plant products have been scientifically tested and reported to posses anti diabetic activity 2635 examples of herbal medicines with proven anti diabetic activity plant part used. The extract exhibits the dosedependent increase in the inhibitory effect on alphaamylase enzyme upto 95. The present study was designed to investigate the glucose uptake of antidiabetic activity crude nhexane,ethanol, methanol and aqueous leaf extracts of cardiospermum halicacabum. Pdf evaluation of antidiabetic activity of medicinal plant. The hypoglycemic activity could be attributed to phytoconstituents found in the plant extract. Homeopathic medicine has accepted the fact that the leaf extracts of the plant under study has shown positive results in inhibiting diabetics. The aim of the present study was to evaluate the active ingredients of s. Studies on invitro antiglycation potential of some. Antidiabetic activity of the compounds isolated from. Pdf antidiabetic activity of ethanolic leaf extract of. Evaluation of in vitro anti diabetic activity of selected. In vitro antidiabetic activity and mechanism of action of. Potential antidiabetic activity of extracts and isolated. The mediumpolar extract of the leaves thus obtained was distilled and simultaneously dried in vacuo using rotatory evaporator b.
This extract was used for in vitro and in vivo analysis of antidiabetic activity. Antidiabetic activity of zizyphus mauritiana 329 bhargava et al. Antidiabetic activity and ijppr, volume 9, issue 7. Invitro and invivo studies of antidiabetic activity of.
Since this claim has not been investigated scientifically, the aim of this study was to evaluate the antidiabetic effect and phytochemical screening of the aqueous and 70% ethanol extracts on alloxaninduced diabetic mice. Antidiabetic activity of nerium indicum leaf extract in alloxan. Also, improved the pathological changes noticed in their kidney and liver. An acute oral toxicity study was performed as per oecd guidelines 423.
Hence, the chemical constituents of the plant extract might help in preventing diabetic complications and may serve as an alternative in the present armamentarium of antidiabetic drugs. The in vivo anti diabetic activity was screened in albino diabetic induced rats 7. Foeniculum vulgare, antidiabetic activity, aqueous extract, streptozotocininduced diabetic rats. Antidiabetic and wound healing activity of catharanthus. Pdf evaluation of antidiabetic activity of medicinal. The present investigation includes the preliminary screening of phytochemicals and evaluation of in vitro antidiabetic activity of psidium guajava leaves extracts. Okolo rural dwellers in nigeria often resort to herbal remedy and dietary control in the treatment of diabetes mellitus dm. Phytochemical investigation and antidiabetic activity of. The prevalence of diabetes mellitus dm is increasing with ageing of the population and life style changes associated with rapid urbanization and westernization. Each extract was dissolved in distilled water before its administration to the diabetic rats. However, we are not certain about the mechanism of the antidiabetic action of the extracts.
Ajuga remota, antidiabetic activity, blood glucose level, diabetes mellitus. Antidiabetic agents from medicinal plants bentham science. Pdf models to study in vitro antidiabetic activity of. The leaves of this plant are used as an antidiabetic agent in nigerian folk medicine, although when aqueous extract given orally did not alter blood glucose level in either normoglycemic or streptozotocin induced diabetic rats. In the traditional system of plant medicine it is usual to use plant formulation and combined extract of plant are used as a drug of choice rather than individual ones 11, to get the benefit of synergism and to find suitable antidiabetic activity. The assay results suggests that the presence of bioactive compounds, could be responsible for the versatile medicinal properties of this plant including diabetes, the extract exhibit the dosedependent increase in inhibitory effect. Antidiabetic activity of alcoholic extract of neem. Phytochemical screening and antidiabetic effect of. The result of this research supported the traditional use of the plant extract for the management of diabetes as claimed by traditional practitioners in ethiopia. Various studies have suggested the role of plant extracts as. Antidiabetic herbal formulations are considered to be more effective for treatment of diabetes. In vitro antidiabetic activity of ethanolic leaf extract. Antidiabetic activity testing was carried out bygiving llse at an oral dose of 250 mgkg body weight to.
Antidiabetic and antihyperlipidemic activities of the leaf. Plant species with antidiabetic properties plant based medicinal products have been known to man since ancient times, subbulakshmi and naik, 2001. Antidiabetic experiments using plant extracts have been conducted using guinea pigs model experiments. In vitro studies on alpha amylase and alpha glucosidase inhibitory activities of selected plant extracts sindhu. Antimicrobial activities of plant extracts at varying concentra tions of 0. In vivo antidiabetic activity of aqueous and ethyl acetate leaf extract.
After oral administration of such extract the blood glucose levels were recorded at specific intervals. This observed antidiabetic activity of this extract might be due to their phytochemical constituents previously reported. However, due to the potential toxicity of the plant extract. The entire plant or its different parts can be used in the form of a whole plant, crude extract, and aqueous decoctions. As the above mentioned plant has shown many pharmacological activities and the only activity which is left behind was the antidiabetic activity. This was prepared by dissolving 2 g of plant extract in 25 ml water in a falcon tube in a hot water bath with vigorous shaking. Antidiabetic activity and phytochemical screening of. Preclinical evaluation of antidiabetic activity of poly. Antidiabetic activity of aqueous extract of sigesbeckia orientalis st. The antidiabetic activity of the chloroform extract of the plant leaves on chronic treatment of streptozotocininduced niddm non insulin dependent diabetes mellitus model diabetic rats was evaluated and the herb possesses antidiabetic activity. Antidiabetic activity of ethanolic extract of hydnocarpus. Ajuga remota, antidiabetic activity, blood glucose level, diabetes mellitus, glibenclamide, phytochemical screening.
Our assay result suggests that methanol extract of caesalpinia digyna exhibit dosedependent increase in percentage inhibitory activity on. The in vitro antiglycation activity of extracts of some traditional antidiabetic plants was studied by determining the degree of nonenzymatic hemoglobin glycosylation. The present findings suggest that, the methanolic extract showed a significant inhibitory effect on glucose diffusion in vitro thus validating the traditional claim of the plant. It is the fourth leading causes of death in the most developed countries and there in substantial evendiced that it in epidemic in many developing and newly industrialized. Apocynaceae leaf extract in alloxan induced diabetic albino rats. Antidiabetic and antioxidant activities of seed extract. The antidiabetic activity in plants may be attributed to the presence of phenolic and flavonoid compounds. Antidiabetic activity medicinal plant aegle marmelos. Antidiabetic activity of terminalia catappa leaf extracts ijpt. The effect of the extract supported the traditional claim of the plant. Materials and methods plant material for the period of sampling, spring is appointed because it is the season when the development and floristic diversity.
Evaluation of antidiabetic activity of plants used in western. Plant species with antidiabetic properties plantbased medicinal products have been known to man since ancient times, subbulakshmi and naik, 2001. Models to study in vitro antidiabetic activity of plants. In vitro antidiabetic activity of cardiospermum halicacabum leaves extracts by stalin.
Pdf in vitro antidiabetic activity of aqueous extract. The selected plant extracts were studied for their effect on inhibition of glycosylation of haemoglobin and glucose transport across yeast cells. After 7 days the extract was filtered through muslin cloth and marc was discarded. Aim of the present study is evaluated various medicinal plants used for antidiabetic activity. Evaluation of in vitro anti diabetic activity of selected plant extracts. Ajuga remota benth is traditionally used in ethiopia for the management of diabetes mellitus. Antidiabetic activity of mediumpolar extract from the. Antidiabetic activity of extracts and fraction of zizyphus. A higher antiinflammatory activity was observed in extract obtained from microwave extraction 64.
Identification and quantification of bioactive compounds present was analysed by hplc. Acorus calamus acoraceae oral administration of methanolic extract of. In our study, the butanol fractions of selected plant species generally have been found more active than other fractions, indicating that compounds having antidiabetic activity are polar in nature which established the significant correlations of polyphenolic and flavonoids to lower down the. Abutilon hirtum extract and fractions exhibited antiinflammatory analgesic, antipyretic and antipyretic activities which may be attributed by the. In vitro antidiabetic activity of ethanolic leaf extract of. Introduction diabetes mellitus is the one of the challenging health. Determination of in vitro antidiabetic effects of zingiber officinale roscoe 603 glucose diffusion inhibition the potential of ginger rhizome extracts to inhibit glucose diffusion into the external solution was investi gated at set time intervals gallagher et al. Antidiabetic activity of aqueous and methanol extract and fractions of. Antidiabetic activity and phytochemical screening of extracts of the. Antidiabetic activity of ethanolic leaf extract of croton zambesicus muell. Anti diabetic medicinal plants open access journals. Antidiabetic activity of mediumpolar extract from the leaves. Hence, the present study is planned to investigate the antioxidant and antidiabetic effects of methanolic extracts barks of c. For treatments, the concentration of aqueous extract was 400 mgkg body weight.
It is evident that these plant extract and compounds derived from them are capable of lowering blood glucose level through different mechanism of action. It was found that the percentage increase of the rate of uptake of glucose into yeast cells was linear in different glucose concentrations used. In vitro analysis of the antidiabetic effect of aqueous extracts of the medicinal plants nigella sativa, eugenia jambolana, andrographis paniculata, gymnema sylvestre. The present work was to evaluate the in vitro anti diabetic activity of methanolic extracts of cinnamomum zeylanicum, piper betle, artocarpus heterophyllus and. Traditional medicines derived from medicinal plants are used by about 60% of the worlds population. Antidiabetic activity of mediumpolar extract from the leaves of stevia rebaudiana bert. Materials and methods plant collection the leaves of the b. Most of these medicinal plants are scientifically validated for.
Antidiabetic activity of the compounds isolated from rhus mysorensis plant extract doi. Medicinal and natural herbal plant products are traditionally used from long time in many countries for the treatment of diabetes mellitus. Medicinal plants with potential antidiabetic activity a. Phytochemical and in vitro antidiabetic activity of. Alphaamylase inhibitory activity alpha amylase ec 3. Antidiabetic activity and phytochemical constituents of. The present investigation suggested that the treatment with foeniculum vulgare exhibited antidiabetic activity in. Conclusion plant extracts have indeed shown to possess potent and selective antimicrobial activity against human pathogens. Bertoni on alloxaninduced diabetic rats bertoni on alloxaninduced diabetic rats himanshu misra, 1, 2 manish soni, 3 narendra silawat, 4 darshana mehta, 1 b. Salacia reticulate the common name of the salacia reticulata is meharimula. Role of plant antioxidants in diabetes has not been undertaken. Zingiber officinale rhizome aqueous extract were examined at concentrations of 5, 10, 20 and 40 gl. The generated data supports the folkloric claims associating s. The leaf latex extract of aloe megalacantha has been used for the management of diabetes mellitus in ethiopian folk medicine.
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